Is marijuana use associated with post-transplant complications in organ transplantation?

There are extant case reports of post-transplant complications attributed to marijuana use including membranous glomerulonephritis, ventricular tachycardia, and tacrolimus toxicity. However, recent studies sugge … Marijuana Use and Organ Transplantation: a Review and Implications for Clinical Practice Curr Psychiatry Rep.

What is the best way to take cannabidiol?

A prescription cannabidiol product (Epidiolex) is approved to be taken by mouth in doses of up to 25 mg/kg daily. Cannabidiol sprays that are applied under the tongue have been used in doses of 2.5 mg for up to 2 weeks. Some reported side effects of cannabidiol include dry mouth, low blood pressure, light headedness, and drowsiness.

Can cannabis be used as a cancer treatment?

We also reviewed online sources, books, and ClinicalTrials.gov for reports or studies on using cannabis as cancer treatment. All case reports published in peer-reviewed journals were compiled and appraised as weak, moderate, or strong based on the quality of evidence provided supporting an anticancer effect.

What are some good clinical trials on medical cannabis?

A Prospective Non randomized Single Arm Clinical Trial. Effect of medical cannabis on thermal quantitative measurements of pain in patients with Parkinson’s disease. Cannabidiol as a new treatment for drug-resistant epilepsy in tuberous sclerosis complex.

Can cannabidiol (CBD) help autoimmune disease?

Cannabidiol ( CBD) has shown in studies and as anecdotal evidence that it may be able to help people manage this lifelong illness. Cannabidiol (CBD) may be able to help with autoimmune disease because of the way it interacts with the immune system.

What is cannabidiol (cbdis)?

Cannabidiolwas found to suppress multiple immune celltypes, suggesting that it may treat a range of autoimmune disorders. CBDis not similar to tetrahydrocannabinol (THC). THCis a psychoactivecompound that causes mind-altering effects when consumed.

Can marijuana help treat autoimmune diseases?

Researchers from the University of South Carolina say that tetrahydrocannabinol, the principal constituent of marijuana, may have another medical use ” treating those with autoimmune disorders. Tetrahydrocannabinol (THC) is known to have analgesic effects so can be used to treat pain.

Can cannabis help with pulmonary fibrosis?

Because there’s inflammation involved with pulmonary fibrosis, anti-inflammatory medications and treatments are usually effective. In one study, researchers found the THC in marijuana to have anti-inflammatory properties, which they feel accounts for the pulmonary function improvement in patients using cannabis.

Can CBD reduce lung inflammation?

Like “9-tetrahydrocannabinol (“9-THC), the most well-studied cannabinoid, CBD decreased lung inflammation in a murine model of acute lung injury potentially through the inhibition of proinflammatory cytokine production by immune cells and suppressing exuberant immune responses (Ribeiro et al., 2015).

What medications are used to treat idiopathic pulmonary fibrosis?

Currently, two drugs are FDA-approved for treatment of idiopathic pulmonary fibrosis (IPF), which is the most common form of PF. These include nintedanib (Ofev®) and pirfenidone (Esbriet®). These medications are called anti-fibrotic agents, meaning that they have shown in clinical trials to slow down the rate of fibrosis or scarring in the lungs.

Can cannabidiol be a useful therapeutic tool for inflammatory lung diseases?

Therefore the present and previous data suggest that in the future cannabidiol might become a useful therapeutic tool for the attenuation and treatment of inflammatory lung diseases. Keywords: Cannabidiol; cannabinoids; inflammation; lipopolysaccharide; pulmonary mechanics.

Is cannabidiol an effective treatment for Tuberous Sclerosis Complex (TSC)?

Importance: Efficacy of cannabidiol has been demonstrated in seizures associated with Lennox-Gastaut and Dravet syndromes but appears not yet to have been established in conditions with primarily focal seizures, such as tuberous sclerosis complex (TSC).

What is Epidiolex (CBD)?

Epidiolex is the only prescription form of CBD available, and it was approved by the U.S. Food and Drug Administration (FDA) in June 2018 for the treatment of seizures in two hard-to-treat forms epilepsy” Lennox-Gastaut syndrome (LGS) and Dravet syndrome.

Is cannabidiol effective for treating Sturge-Weber syndrome refractory seizures?

This study suggests that cannabidiol may be well tolerated as adjunctive medication for seizure management and provides initial data supporting further study of cannabidiol in individuals with Sturge-Weber syndrome. Cannabidiol Treatment for Refractory Seizures in Sturge-Weber Syndrome Pediatr Neurol.

Can cannabidiol (CBD) improve cognitive impairment after chronic cerebral hypoperfusion?

Diabetes and aging are risk factors for cognitive impairments after chronic cerebral hypoperfusion (CCH). Cannabidiol (CBD) is a phytocannabinoid present in the Cannabis sativa plant. It has beneficial effects on both cerebral ischemic diseases and diabetes.

Can cannabinoids improve cerebral perfusion in Alzheimer’s disease?

Considering that cerebral blood flow in AD contributes to the reduction of oxygen and nutrients in brain ( Iadecola, 2004 ), it can be suggested that treatments improving cerebral perfusion such as cannabinoids are advantageous in AD.

Does cannabidiol work for Dravet syndrome?

Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome Among patients with the Dravet syndrome, cannabidiol resulted in a greater reduction in convulsive-seizure frequency than placebo and was associated with higher rates of adverse events.

What is cannabidiol?

Cannabidiol (CBD) is a phytocannabinoid discovered in 1940. It is one of some 113 identified cannabinoids in cannabis plants and accounts for up to 40% of the plant’s extract.

What is the PMID for cannabidiol?

PMID 16746878. ^ Mechoulam R, Shvo Y (December 1963). “Hashish. I. The structure of cannabidiol”. Tetrahedron. 19 (12): 2073″8. doi: 10.1016/0040-4020 (63)85022-x. PMID 5879214. ^ a b c d e f g h i j “FDA Regulation of Cannabis and Cannabis-Derived Products, Including Cannabidiol (CBD) (General)”. US Food and Drug Administration (FDA).

How effective is cannabidiol for treating seizures?

For total seizures (all seizure types), the median frequency of seizures per month decreased from 24.0 to 13.7 in the cannabidiol group (adjusted reduction, 28.6%), versus a decrease from 41.5 to 31.1 in the placebo group (adjusted reduction, 9.0%).