Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) that affects an estimated 2.3 million people worldwide ( 1 ). The symptoms of MS are highly varied but frequently include pain, muscle spasticity, fatigue, inflammation, and depression.
Can cannabis help multiple sclerosis (MS)?
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) that affects an estimated 2.3 million people worldwide (1). The cannabis plant contains many biologically active chemicals, including ~60 cannabinoids (3). Currently, many PwMS utilize cannabis to manage a variety of symptoms.
Can CBD be used to treat pain in MS?
One of these drugs, called Sativex, is an oral spray containing CBD and THC in a 1: 1 ratio. This product has been officially approved as an adjunct in the treatment of neuropathic pain in MS. In addition, this product, based on cannabinoids, has been studied for the treatment of other symptoms of MS.
Can CBD counteract the development of experimental multiple sclerosis?
The purpose of this study was to determine if pure (isolated) CBD can counteract the development of experimental multiple sclerosis. Cannabinoids have been found to activate so-called pathways across multiple immune and non-immune cells, however, it is not yet known what impact CBD has on these pathways in treating MS.
Do cannabinoids cause vomiting?
The anti-emetic effect of cannabinoids has been shown across a wide variety of animals that are capable of vomiting in response to a toxic challenge. CB(1) ag … Regulation of nausea and vomiting by cannabinoids Br J Pharmacol. 2011 Aug;163(7):1411-22.doi: 10.1111/j.1476-5381.2010.01176.x. Authors
Does cannabis help with nausea and vomiting?
The primary non-psychoactive compound in cannabis, cannabidiol (CBD), also suppresses nausea and vomiting within a limited dose range.
Can cannabidiol (CBD) be used to treat chemotherapy-induced nausea and vomiting?
Preclinical research indicates that cannabinioids, including CBD, may be effective clinically for treating both nausea and vomiting produced by chemotherapy or other therapeutic treatments. © 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society.
What are the side effects of cannabidiol (CBD)?
Conversely, some studies reported that this cannabinoid can induce some side effects, including inhibition of hepatic drug metabolism, alterations of in vitro cell viability, decreased fertilization capacity, and decreased activities of p-glycoprotein and other drug transporters.
How effective is cannabidiol for epilepsy?
Cannabidiol has been shown to reduce the frequency of seizures in animal models of epilepsy. Open-label data from a trial of a plant-derived pharmaceutical formulation of cannabidiol suggest that this medication may be effective in drug-resistant cases of epilepsy.
Does cannabidiol reduce drop seizures in the Lennox”Gastaut syndrome?
Cannabidiol in the Lennox”Gastaut Syndrome This randomized trial showed that two different doses of oral cannabidiol resulted in greater reductions in drop-seizure and total-seizure frequencies tha… Effect of Cannabidiol on Drop Seizures in the Lennox”Gastaut Syndrome | NEJM
Does cannabidiol have any adverse effects on the liver?
Six patients in the 20-mg cannabidiol group and 1 patient in the 10-mg cannabidiol group discontinued the trial medication because of adverse events and were withdrawn from the trial. Fourteen patients who received cannabidiol (9%) had elevated liver aminotransferase concentrations. Conclusions
How does cannabidiol inhibit paclitaxel-induced neuropathic pain?
Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT(1A) receptors without diminishing nervous system function or chemotherapy efficacy Br J Pharmacol. 2014 Feb;171(3):636-45.doi: 10.1111/bph.12439. Authors
What is the role of cannabidiol (CBD) in rat chronic inflammatory and neuropathic pain?
Costa B., Trovato A.E., Comelli F., Giagnoni G., Colleoni M. The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain.
Does cannabidiol help with pain relief?
Cannabidiol Like THC, cannabidiol has been shown to reduce the pain associated with various neuropathic pain models in rodents [15,38,40,45,46,47]. However, it should be noted that cannabidiol has a maximal analgesic effect (efficacy) that is only half of that observed for THC .
Can cannabinoid drugs help treat neuropathic pain?
Cannabinoid drugs are emerging as a promising class of drugs to treat neuropathic pain and have been tested for analgesic effects in a range of chronic pain conditions. Data show that cannabinoids are often effective in individuals with refractory pain receiving concomitant analgesic drugs.
What is the neuroprotective effect of cannabidiol in Newborn hypoxic-ischemic brain damage?
The neuroprotective effect of cannabidiol in an in vitromodel of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors. Neurobiol. Dis.37, 434″440. 10.1016/j.nbd.2009.10.023 [PubMed] [CrossRef] [Google Scholar]
How does cannabidiol (CBD) affect psychiatric disorders?
Beneficial effects of cannabidiol (CBD) have been described for a wide range of psychiatric disorders, including anxiety, psychosis, and depression. The mechanisms responsible for these effects, however, are still poorly understood.
What is cannabidiol?
Cannabidiol (CBD) is a non-psychotomimetic phytocannabinoid derived from Cannabis sativa. It has possible therapeutic effects over a broad range of neuropsychiatric disorders. CBD attenuates brain damage associated with neurodegenerative and/or ischemic conditions.
Is cannabidiol a neuromodulator or neuroprotector?
In the past decade, cannabidiol (CBD), a non-psychotropic phytocannabinoid, has been shown to have compensatory effects both on the ECS and as a neuromodulator and neuroprotector in models such as 6-hydroxydopamine (6-OHDA), 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), and reserpine, as well as other PD models.
Is cannabidiol legal in Switzerland?
While THC remains illegal, cannabidiol is not subject to the Swiss Narcotic Acts because this substance does not produce a comparable psychoactive effect. Cannabis products containing less than 1% THC can be sold and purchased legally.